– Lite er kjent om menns helse og risikoen for spontanabort og dødfødsler
Stipendiat Shwe Sin Win jobber med å kartlegge fars helse.
Name: Shwe Sin Win
Age: 35 years
Position: PhD fellow
Place of work: Department of Global Health and Primary Care, Faculty of Medicine, University of Bergen
Background: M.B., B.S. and MPH
There is a large gap in knowledge regarding men’s health and the combination of risk factors in men and women as they relate to fetal lossesShwe Sin Win, stipendiat
– This PhD project represents a new initiative that adds men’s health to the maternal-child health paradigm with the objectives of evaluating the extent to which paternal lifestyle indicators associate with late miscarriages and stillbirths independent of or in tandem with maternal risk factors.
– Evaluating paternal cardiovascular and metabolic risk factors for their association with late miscarriages and stillbirths independent of or in tandem with maternal risk factors.
Why is this important?
– A large percentage of pregnancies result in fetal losses where 12-15 percent of recognized pregnancies result in miscarriage by 20 weeks gestation, and where rates increase dramatically with high maternal ages.
– While stillbirths occur less frequently than miscarriages they are devastating events for expecting parents. Numerous studies have evaluated women’s risk factors for stillbirth deliveries, as well as miscarriages, but little is known regarding the contribution of paternal factors to these outcomes. There is a large gap in knowledge regarding men’s health and the combination of risk factors in men and women as they relate to fetal losses.
– The sum of the available evidence from the literature suggests that indicators of men’s health and lifestyle could be potential risk factors for early and late miscarriages and stillbirth deliveries. However, the literature available on men is sparse and fragmented and generally fails to take account of a wide range of maternal risk factors. Further, the majority of studies, particularly from infertility or assisted reproduction clinics suffer from small numbers and lack phenotypic information hindering research of the importance of paternal factors.
This project aims to fill that gap.
- Are paternal cardiovascular and diabetic risk factors (hypercholesterolemia, hyperglycemia, insulin resistance, diabetes mellitus, and high blood pressure) associated with late miscarriage and stillbirth deliveries when taking account of maternal risk factors?
- Is a paternal family history of stroke, diabetes mellitus, and acute myocardial infarction prior to 60 years of age associated with late miscarriage and stillbirth deliveries independent of maternal risk factors?
- Are paternal lifestyle indicators (obesity, central fat patterning, daily cigarette smoking, number of cigarettes smoked daily, alcohol intake, and educational level) associated with late miscarriage and stillbirth deliveries when taking account of maternal risk factors?
How will the project be carried out? Do you have a schedule?
– This PhD project is planned to be fulfilled within three years (from 15.08.2022 to 14.08.2025). We aim to present preliminary and final findings in various occasions, including research group meetings, national and international relevant conferences. The project will be an article-based thesis and we will aim to publish these papers in relevant international scientific journals.
What is your hypothesis?
– Paternal cardiovascular and diabetic risk factors; Paternal family history of stroke, diabetes, acute myocardial infarction; and Paternal lifestyle indicators will associate with pregnancy losses independent of maternal risk factors.
Who initiated the project, and who is involved?
– Dr Grace Margrethe Egeland (Senior researcher/Professor University of Bergen) initiated the project as the principal investigator (PI) together with Dr Kari Klungsøyr (Senior Physician/ Professor University of Bergen) as co-applicant. Dr Gerhard Sulo (Associate Professor, University of Bergen) is also involved as the main supervisor of the PhD student.
Stiftelsen Dam requires user participation. How is that taken care of in this project?
– This PhD project is part of the umbrella project «Men’s health and risks for miscarriage and stillbirth deliveries: From research to practice». PI will be conducting meetings and workshops with stakeholders and researchers, results communication, and planning and conducting a final results workshop. A stakeholder reference group (LUB, Den norske jordmorforening, and doctors and midwives employed by Helse Bergen) will help guide the project through all phases with routine meetings.